Le CRIOAc Lyon a publié de nombreux "case report" dans le domaine des IOA, dans des revues médicales internationales. L'apprentissage basé sur l'expérience acquise dans le traitement individuel de chaque patient, a pour nous des vertus pédagogiques importantes, et sont précieuses dans l'élaboration des algorithmes de prise en charge et dans l'évaluation des stratégies médico-chirurgicales.

2021

Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin‑rifampin treatment and complex reconstruction were needed for the cure
Arthroplasty (2021) 3:43 https://doi.org/10.1186/s42836-021-00097-1
free access international
Background: Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii, a strictly intracellular pathogen that can cause acute and chronic infection. Chronic Q fever can occur in immunocompetent as well as in immunocompromised hosts, as a persistent localized infection. The main localizations are endocardial, vascular and, less frequently, osteoarticular. The most frequent... Lire la suite »
Arthroscopic « Debridement Antibiotics and Implant Retention » With Local Injection of Personalized Phage Therapy to Salvage a Relapsing Pseudomonas Aeruginosa Prosthetic Knee Infection
Front Med (Lausanne). 2021 May 5;8:569159. doi: 10.3389/fmed.2021.569159. eCollection 2021.
international
Bacteriophages are viruses that specifically target bacteria. They are considered to have a high potential in patients with prosthetic joint infection (PJI), as they have a synergistic anti-biofilm activity with antibiotics. We report here the case of an 88-year-old man (63 kg) with relapsing Pseudomonas aeruginosa prosthetic knee infection. The patient had severe alteration of the general... Lire la suite »

2020

The Potential Innovative Use of Bacteriophages Within the DAC ® Hydrogel to Treat Patients With Knee Megaprosthesis Infection Requiring « Debridement Antibiotics and Implant Retention » and Soft Tissue Coverage as Salvage Therapy
Front Med (Lausanne). 2020 Jul 31;7:342. doi: 10.3389/fmed.2020.00342. eCollection 2020.
free access international
Infection is the most dramatic complication in patients with knee megaprosthesis. Its management is more complex in comparison with patients with primary arthroplasty, with a high risk of relapse. Lytic bacteriophages are considered to have a high potential in patients with prosthetic joint infection as it has been demonstrated that they have a synergistic anti-biofilm... Lire la suite »

2019

2018

2017

Intercalary diaphyseal endoprosthetic reconstruction for tibial septic non-union in an elderly patient: A case report
Orthop Traumatol Surg Res. 2017 Dec;103(8):1217-1220. doi: 10.1016/j.otsr.2017.09.011. Epub 2017 Sep 29.
free access international
The surgical treatment of septic non-union is challenging and carries a high failure rate. Bone defect management and fracture site stabilisation are key treatment objectives. We report the case of a 75-year-old woman who underwent intercalary endoprosthetic reconstruction of a large tibial defect due to septic non-union after two previous treatment failures. The two-stage procedure... Lire la suite »

2016

Three-step sequential management for knee arthroplasty after severe ballistic injury: Two cases
Orthop Traumatol Surg Res. 2016 Feb;102(1):131-4. doi: 10.1016/j.otsr.2015.08.014. Epub 2016 Jan 7.
free access international
Management of knee bone loss after gunshot trauma requires a multidisciplinary approach. Two cases of knee arthroplasty after devastating ballistic trauma are reported. Treatment comprised several steps: sampling, bone resection, reinforced cement spacer, latent sepsis control, and prosthetic reconstruction. The patients showed no neurovascular disorder and had a functioning extensor mechanism. At follow-up of at... Lire la suite »

2015

2014

Culture-negative Prosthetic Joint Arthritis Related to Coxiella Burnetii
Am J Med . 2014 Aug;127(8):786.e7-786.e10. doi: 10.1016/j.amjmed.2014.03.013. Epub 2014 Mar 22.
international
Background: The number of hip and knee arthroplasty procedures is steadily increasing as life expectancy increases. Coxiella burnetii may be responsible for culture-negative prosthetic joint arthritis and is associated with antibiotic failure and repeated surgeries. We report the first case series of C. burnetii-related culture-negative prosthetic joint arthritis. Methods: Cases were retrieved from the French... Lire la suite »