Management of Gram-positive multiresistant bacteria prosthetic joint infection: a narrative review on current and innovative strategies
Prosthetic joint infection (PJI) is a devastating complication of arthroplasty surgery, mostly caused by Gram-positive pathogens, including S. aureus and coagulase-negative staphylococci (CNS). Multidrug resistance is of major concern in this setting: i) it can negatively impact outcome, restricting the use of the most effective antimicrobials; ii) it may influence the choice of surgical strategies; and iii) it restrains the therapeutic options to newly labelled antimicrobials with limited experience in PJI.