Efficacy of bacteriophages in a S. aureus non-diabetic or diabetic foot infection murine model

This study investigated the in vivo efficiency of three combined bacteriophages compared to linezolid, in two mouse models (non-diabetic or diabetic) of S. aureus foot infection. In both models, a single injection of bacteriophages showed a significant antibacterial efficacy in the hindpaw. Linezolid was as effective as bacteriophages in non-diabetic animals but ineffective in diabetic animals. These findings support further preclinical and clinical studies for the development of phage therapy.