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You can directly and actively participate in this research:<\/strong><\/p>\n The number of new antibiotics brought to market has been steadily declining<\/strong> since the 1980s, while antibiotic resistance is becoming widespread<\/strong> globally. According to the WHO, in 2050, there will be more deaths due to antibiotic resistance than to cancer<\/strong>.<\/p>\n Causes of mortality in 2014 and projected deaths due to antibiotic resistance in 2050, according to the O\u2019Neill report<\/a> published in 2014<\/p><\/div>\n<\/div>\n<\/div>\n An increasing number of patients are presenting infections caused by multidrug-resistant bacteria; for some, no antibiotic remains effective.<\/strong> This issue is found in infections of all kinds, and the Lyon team has set itself the goal of addressing what is becoming a major public health challenge. They propose an alternative to antibiotics: phage therapy, as part of the PHAGEin<\/em>LYON Clinic<\/strong><\/a> project.<\/p>\n This therapy uses natural bacterial predators\u2014bacteriophages or phages\u2014to destroy bacteria and eradicate bacterial infections. Phages<\/strong> are viruses<\/strong> found in large quantities in nature<\/strong> (billions per liter of water) and exclusively target bacteria<\/strong>. Each phage species attacks only one bacterial species, making it a highly targeted weapon<\/strong>, unlike antibiotics, which also attack beneficial bacteria (e.g., digestive flora). To do this, the phage attaches itself to the surface of its bacterial prey, injects its DNA into the bacterium, and then hijacks the bacterial machinery<\/strong> to produce hundreds of virus copies. These copies, upon release, literally cause the bacterium to burst, thereby destroying it permanently. Our team has treated around 100 patients with phage therapy<\/strong><\/a> on an exceptional basis<\/strong>, under the supervision of the French National Agency for Medicines and Health Products Safety (ANSM)<\/strong><\/a>. These patients had prosthetic infections or severe multidrug-resistant bacterial infections, with conventional treatments failing and their vital or functional prognosis at risk<\/strong>. These patients were in a therapeutic deadlock<\/strong>. They were treated \u201con compassionate grounds, and thus in a highly exceptional manner.\u201d<\/strong> Because we have obtained very encouraging results, we must move beyond exceptional use!<\/p>\n <\/p>","protected":false},"excerpt":{"rendered":" With the HCL FOUNDATION, support research on bone and joint infections (BJI) in general, and particularly the PHAGEinLYON Clinic project\u2014Fighting antibiotic resistance: bacteria-eating viruses! You can directly and actively participate in this research: <\/p>\n Context The number of new antibiotics brought to<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2962","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/pages\/2962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/comments?post=2962"}],"version-history":[{"count":133,"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/pages\/2962\/revisions"}],"predecessor-version":[{"id":6551,"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/pages\/2962\/revisions\/6551"}],"wp:attachment":[{"href":"https:\/\/www.crioac-lyon.fr\/en\/wp-json\/wp\/v2\/media?parent=2962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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<\/div>\nContext<\/h2>\n
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\nAt the national level, an Antibiotic Resistance Interface has been established by INSERM<\/strong><\/a> to coordinate efforts against antibiotic resistance.
\nAt the Hospices Civils de Lyon<\/strong><\/a>, the CRIOAc Lyon<\/strong><\/a> team has observed that implant-related infections (knee and hip prostheses), even in the absence of antibiotic resistance, are particularly difficult to control<\/strong> and can become chronic<\/strong>, with severe impacts on quality of life<\/strong>: partial or total disability, loss of autonomy, or even death from sepsis.<\/p>\n
\nPhages: Viruses That Are Friends to Humans<\/h2>\n
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<\/p>\nMoving Beyond Exceptional Use!<\/h2>\n
Project Objective: Phage Therapy 2.0<\/h2>\n
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<\/h2>\nSupport CRIOAc Lyon Research<\/h2>\n
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